Dr Akeel Alisa

Consultant Gastroenterologist, Hepatologist & General Physician

BSC. , MB;BCHIR (CAMBR.), MRCP (GASTRO.), MD RES. (UCL), FRCP (LONDON)

Dr Akeel Alisa was awarded his medical degree from Cambridge University, Girton College. He trained at various leading London hospitals including King’s College, University College London and St George’s and gained experience in all aspects of Gastroenterology, Hepatology, Endoscopy and General Medicine. He was awarded Membership of the Royal College of Physicians (London) in 1998 and received his MD from UCL in 2012.

He was appointed as a Consultant Gastroenterologist & General Physician at The Royal Free NHS Trust, Barnet & Chase Farm Hospitals. He is local lead in alcohol services and endoscopy training. He is faculty member at St George’s National Endoscopy Training Centre & United European Gastroenterology (Vienna).

Special interests:

1) Gastroenterology; Irritable Bowel Syndrome, Coeliac disease, heartburn & acid reflux, abdominal pain, constipation, diarrhoea, Inflammatory Bowel Disease.

2) Upper and Lower Diagnostic & therapeutic Endoscopy; Gastroscopy, Colonoscopy, Flexible Sigmoidoscopy, complex polyp removal by endoscopic mucosal resection (EMR), stricture dilatation & stent insertion, Gastrointestinal bleeding, feeding tubes (PEG/PEJ) and Capsule Endoscopy.

3) Hepatology; abnormal liver tests, viral hepatitis, alcohol misuse, cirrhosis, fatty liver & non-invasive test for liver scarring (Fibroscan).

He undertook research at the Institute of Hepatology, focusing on cirrhosis & UK first living related liver transplant. He published numerous papers and has been an invited speaker at various national and international meetings as well as after dinner speeches for the George Best charity.

He believes in informed choice and a multidisciplinary approach in treating patients.

Specialities

  • Hepatology
  • Gastroenterology

Clinical interests

  • Gastroenterology; Irritable Bowel Syndrome, Coeliac disease, heartburn & acid reflux, abdominal pain, constipation, diarrhoea, Inflammatory Bowel Disease.
  • Upper and Lower Diagnostic & therapeutic Endoscopy
  • Hepatology; abnormal liver tests, viral hepatitis, alcohol misuse, cirrhosis, fatty liver & non-invasive test for liver scarring (Fibroscan).

Research interests

  • He undertook research at the Institute of Hepatology, focusing on cirrhosis & UK first living related liver transplant.
  • He has published numerous peer reviewed papers and abstracts on Liver disease (Viral Hepatitis, Chronic liver disease, Liver support, Liver transplant, alcohol misuse), Gastrointestinal disease (Inflammatory bowel disease, Gastrointestinal bleeding).

Procedures Offered

  • Upper and Lower Diagnostic & therapeutic Endoscopy
  • Gastroscopy
  • Colonoscopy
  • Flexible Sigmoidoscopy
  • Complex polyp removal by endoscopic mucosal resection (EMR)
  • Stricture dilatation & stent insertion
  • Management of Gastrointestinal bleeding
  • Feeding tubes insertion (PEG/PEJ)
  • Capsule Endoscopy

Induction of latency-associated peptide (transforming growth factor-β(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-α production in a transforming growth factor-β-dependent manner. Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S. Immunology. 2011 Jul;133(3):278-87.

Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Anastasiou J, Alisa A, Virtue S, Portmann B, Murray-Lyon I, Williams R. Eur J Gastroenterol Hepatol. 2010 Apr;22(4):474-80.

Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease. Behboudi S, Alisa A, Boswell S, Anastassiou J, Pathan AA, Williams R. Br J Cancer. 2010 Feb 16;102(4):748-53. Epub 2010 Jan 19.

Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells. Alisa A, Boswell S, Pathan AA, Ayaru L, Williams R, Behboudi S. J Immunol. 2008 Apr 1;180(7):5109-17

Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization. Ayaru L, Pereira SP, Alisa A, Pathan AA, Williams R, Davidson B, Burroughs AK, Meyer T, Behboudi S. J Immunol. 2007 Feb 1;178(3):1914-22

Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients. Alisa A, Ives A, Pathan AA, Navarrete CV, Williams R, Bertoletti A, Behboudi S. Clin Cancer Res. 2005 Sep 15;11(18):6686-94.,

Alpha-fetoprotein impairs APC function and induces their apoptosis. Um SH, Mulhall C, Alisa A, Ives AR, Karani J, Williams R, Bertoletti A, Behboudi S. J Immunol. 2004 Aug 1;173(3):1772-8.,

Use of fibrin glue (beriplast) in the management of bleeding gastric varices. Datta D, Vlavianos P, Alisa A, Westaby D. Endoscopy. 2003 Aug;35(8):675-8.

Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, Ludwiczek O, Shawcross D, Zoller H, Alisa A, Mookerjee RP, Graziadei I, Datz C, Trauner M, Schuppan D, Obrist P, Vogel W, Williams R. J Hepatol. 2003 Apr;38(4):419-25

Adult-to-adult living donor liver transplant: UK experience. Williams RS, Alisa AA, Karani JB, Muiesan P, Rela SM, Heaton ND. Eur J Gastroenterol Hepatol. 2003 Jan;15(1):7-14.,

Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. Jalan R, Sen S, Steiner C, Kapoor D, Alisa A, Williams R. J Hepatol. 2003 Jan;38(1):24-31., PMID: 12480556

Living related adult-to-adult liver transplantation: meeting the donor shortage. Williams R, Alisa A, Karani J, Rela M, Heaton N. Antiviral Res. 2001 Nov;52(2):217-23

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. Maini MK, Boni C, Lee CK, Larrubia JR, Reignat S, Ogg GS, King AS, Herberg J, Gilson R, Alisa A, Williams R, Vergani D, Naoumov NV, Ferrari C, Bertoletti A. J Exp Med. 2000 Apr

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